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Named reactions

Get references and more from over 225 named organic chemical reaction

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Protecting Groups

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tert-Butyldiphenylsilyl ether (TBDPS)

Protection

 
Reagents
Solvents
Temperature
Time
Yield
TBDPSCl, Imidazole
DMF
0 °C - RT
60 min - ON
90-95 %
TBDPSCl, Imidazole
THF
0 °C - RT
18 - 52 h
82-92 %
TBDPSCl, Imidazole, DMAP
CH2Cl2
RT
12 h
85 %
TBDPSCl, DMAP
CH2Cl2
RT
2 h
98 %
TBDPSCl, Et3N, DMAP
CH2Cl2
0 °C - RT
4 h
96 %
TBDPSCl, Imidazole
CH2Cl2
RT
30 min
100 %

Deprotection

 
Reagents
Solvents
Temperature
Time
Yield
n-Bu4N+ F-
THF
0 - 70 °C
15 min - 7 h
80-97 %
TASF
CH2Cl2
0 °C to RT
60 min
95 %
HF
MeCN, H2O
RT
60 min
95 %
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