Synarchive logo
Google+ Facebook Twitter RSS Feed
Support this website
Synarchive is free but requires a lot of work. If you enjoy and find it useful, please support us by making a donation.
Named reactions

Get references and more from over 229 named organic chemical reaction

Go to the named reaction index

Protecting Groups

Get the conditions needed to install/remove a wide range of protecting groups.

Go to the protecting groups index

Search synthesis

Trimethylsilyl ether (TMS)

Protection

 
Reagents
Solvents
Temperature
Time
Yield
TMSCl, Pyr
CH2Cl2
0 °C
15 min
96 %
TMSOTf, Et3N
CH2Cl2
-10 to -5 °C
60 min
72 %
TMSOTf, 2,6-Lutidine
CH2Cl2
RT
4 h
100 %
TMSCN
CH2Cl2
RT
15 h
82 %

Deprotection

 
Reagents
Solvents
Temperature
Time
Yield
HCl
THF, H2O
0 °C - RT
60 min - 6 h
89-100 %
homepage - authors - molecules - named reactions - protecting groups - advanced search - contact
© 2011-2017 SynArchive