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Named reactions

Get references and more from over 229 named organic chemical reaction

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Protecting Groups

Get the conditions needed to install/remove a wide range of protecting groups.

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Triisopropylsilyl ether (TIPS)

Protection

 
Reagents
Solvents
Temperature
Time
Yield
TIPSCl, DMAP
DMF
RT
16 h
100 %
TIPSCl, DMAP
Et3N
RT
25 h
95 %

Deprotection

 
Reagents
Solvents
Temperature
Time
Yield
n-Bu4N+ F-
THF
-30 °C - RT
30 min - 4 h
84-95 %
HF
MeCN
RT
2 h
91 %
TASF
THF
0 °C
5 min
96 %
HCl
MeOH, H2O
RT
15 h
81 %
Et3N.3HF
THF
RT
2.5 d
100 %
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