Ethoxyethyl acetal (EE)

Ethoxyethyl acetal (EE) scheme

Protection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • VinylOEt Pyr.TsOH
    CH2Cl2
    RT
    90 min
    85 %
    intermediate structure
    VinylOEt, Pyr.TsOH
    CH2Cl2
    RT, 90 min, 85%
    intermediate structure

Deprotection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • TsOH
    MeOH CH2Cl2
    90 °C
    60 min
    99 %
    intermediate structure
    TsOH
    MeOH, CH2Cl2
    90 °C, 60 min, 99%
    intermediate structure
  • TsOH
    THF H2O
    RT
    2 h
    82 %
    intermediate structure
    TsOH
    THF, H2O
    RT, 2 h, 82%
    intermediate structure