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Named reactions

Get references and more from over 225 named organic chemical reaction

Go to the named reaction index

Protecting Groups

Get the conditions needed to install/remove a wide range of protecting groups.

Go to the protecting groups index

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Acetate (Ac)

Protection

 
Reagents
Solvents
Temperature
Time
Yield
Ac2O, DMAP
CH2Cl2
RT
30 min - ON
66-95 %
Ac2O, DMAP
Pyr
RT
30 min - 25 h
66-96 %
Ac2O, Et3N, DMAP
CH2Cl2
0 °C - RT
30 min - 20 h
76-99 %
Ac2O, DMAP
PhH
0 - 35 °C
10 h
84 %
Ac2O
Pyr
RT - Reflux
15 min - 12 h
73-100 %
I2
Ac2O
RT
10 min
92 %
Sc(OTf)3
Ac2O
0 °C
2 h
98 %
BF3.OEt2
AcOH
50 °C
18 h
96 %
Ac2O, Pyr
CH2Cl2
RT
24 h
92 %

Deprotection

 
Reagents
Solvents
Temperature
Time
Yield
K2CO3
MeOH
0 °C - RT
15 min - 4 h
82-100 %
KOH
MeOH, H2O
Reflux
2 h
85-100 %
LiOH
THF, H2O
RT
60 min
92 %
NH3
MeOH
0 °C
30 min
90 %
HCl
H2O
RT
2 h
80 %
NaOEt
EtOH
4 °C - RT
10 h
70 %
KOH
EtOH
RT
20 min
80 %
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