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Named reactions

Get references and more from over 229 named organic chemical reaction

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Protecting Groups

Get the conditions needed to install/remove a wide range of protecting groups.

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4-Methoxybenzyl ether (PMB)

Protection

 
Reagents
Solvents
Temperature
Time
Yield
Cl3C(=NH)OCH2(p-MeOPh), Sc(OTf)3
PhMe
0 °C
2 h
94 %
Cl3C(=NH)OCH2(p-MeOPh), TfOH
CH2Cl2
0 °C
3 h
75 %
Cl3C(=NH)OCH2(p-MeOPh), La(OTf)3
THF
RT
3 h
90 %

Deprotection

 
Reagents
Solvents
Temperature
Time
Yield
DDQ
CH2Cl2, H2O
RT
60 min
84-97 %
DDQ
CH2Cl2, Buffer (pH = 7)
RT
60 min
76 %
DDQ
CH2Cl2
RT
18 h
90 %
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