Benzaldehyde acetal

Benzaldehyde acetal scheme

Protection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • PhCHO Pyr.TsOH
    PhH
    Reflux
    4.5-24.5 h
    74-83 %
    intermediate structure
    PhCHO, Pyr.TsOH
    PhH
    Reflux, 24.5 h, 83%
    intermediate structure
    intermediate structure
    PhCHO, Pyr.TsOH
    PhH
    Reflux, 4.5 h, 74%
    intermediate structure

Deprotection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • H2 Pd(OH)2
    EtOH
    RT
    30 min
    84 %
    intermediate structure
    H2, Pd(OH)2
    EtOH
    RT, 30 min, 84%
    intermediate structure