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Named reactions

Get references and more from over 229 named organic chemical reaction

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Protecting Groups

Get the conditions needed to install/remove a wide range of protecting groups.

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Acetonide

Protection

 
Reagents
Solvents
Temperature
Time
Yield
2,2-Dimethoxypropane, Camphorsulfonic acid
CH2Cl2
0 °C - RT
2 - 7 h
82-86 %
2,2-Dimethoxypropane, Pyr.TsOH
DMF
RT
60 min
88 %
2-Methoxypropene, Camphorsulfonic acid
THF
RT
18 h
95 %
CuSO4
Acetone
RT
36 h
83 %

Deprotection

 
Reagents
Solvents
Temperature
Time
Yield
HCl
MeOH, H2O
-12 °C - RT
5 h - 3d
65-85 %
HCl
THF, H2O
RT
5 h
92 %
CF3CO2H
MeCN, H2O
0 °C - RT
45 min
85 %
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