Wolff Rearrangement

Schematic representation of the Wolff Rearrangement.
Mechanism of the Wolff Rearrangement
Mechanism of the Wolff Rearrangement
Sample reactions
intermediate structure
Et3N
MeOH
RT, 3 h, 72%
intermediate structure
intermediate structure
Ag2O
MeOH
65 °C, , 69% (3 steps)
intermediate structure
intermediate structure intermediate structure
NaHCO3
THF, H2O
RT, 2 h, 90%
intermediate structure
intermediate structure
TMS2NH
THF
RT, 6 h, 68% (3 steps)
intermediate structure