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Named Reactions
Protecting Groups
Weinreb Ketone Synthesis
Mechanism of the Weinreb Ketone Synthesis
Original publication
Tetrahedron Lett.. 1981, 22, 3815.
Org. Lett.. 2005, 7, 5845.
Reviews
J. Prakt. Chem.. 1997, 339, 517.
J. Prakt. Chem.. 2000, 342, 340.
Sample reactions
info
VinylMgBr
THF
0 °C, 60 min, 95%
info
AllylMgBr
THF
0 °C, , 93%
info
n-C9H19MgBr
THF
-30 to 0 °C, 60 min, 80%
info
t-BuLi
Et2O
-23 °C, 4.5 h, 52%
info
THF
-78 to 0 °C, 30 min, 71%
info
n-BuLi
THF
-78 °C, 3 h, 96%
info
MeMgBr
THF
-30 to -5 °C, 1 h, 98%