Vilsmeier-Haack Formylation

Schematic representation of the Vilsmeier-Haack Formylation.
Mechanism of the Vilsmeier-Haack Formylation
Mechanism of the Vilsmeier-Haack Formylation
Sample reactions
intermediate structure
POCl3
DMF
0 to 95 °C, 2.5 h, 90-96%
intermediate structure
intermediate structure
POCl3
DMF
-30 °C, 20 min, 89%
intermediate structure
intermediate structure
POCl3, DMF
DCE
-10 °C to RT, 40 min, 71%
intermediate structure
intermediate structure
POCl3
DMF
0 to 35 °C, 60 min, 99%
intermediate structure