Trost Asymmetic Allylation Alkylation

Schematic representation of the Trost Asymmetic Allylation Alkylation.
Mechanism of the Trost Asymmetic Allylation Alkylation
Mechanism of the Trost Asymmetic Allylation Alkylation
Sample reactions
intermediate structure intermediate structure
Pd2(dba)3.CHCl3, n-Bu4N+ Cl-
CH2Cl2
RT, 12 h, 89%
intermediate structure
intermediate structure intermediate structure
(n3-C3H3PdCl)2, Et3N
CH2Cl2
RT, 8 h, 72%
intermediate structure
intermediate structure
(n3-C3H3PdCl)2, Trimethylsilylphthalimide
THF
40 °C, 8.5 h
intermediate structure