Tiffeneau-Demjanov Rearrangement

Mechanism of the Tiffeneau-Demjanov Rearrangement

Original publication	Compt. Rend.. 1937, 205, 54. J. Russ. Phys. Chem.. 1903, 35, 26. Tetrahedron: Asymmetry. 2005, 16, 3628.
Reviews	Comp. Org. Syn.. 1991, 3, 777. Org. React.. 1960, 11, 157. Tetrahedron. 1993, 49, 1649.

Sample reactions

NaNO2, NaOAc

AcOH

0 °C, , 80%

(CO2H)2, NaNO2

H2O

RT, 12 h, 77%