Sandmeyer Isatin Synthesis

Schematic representation of the Sandmeyer Isatin Synthesis.
Mechanism of the Sandmeyer Isatin Synthesis
Mechanism of the Sandmeyer Isatin Synthesis
Original publication
Review
Sample reactions
intermediate structure
Cl3CCH(OH)2, NH2OH.HCl, Na2SO4
H2O
50-60 °C
intermediate structure
intermediate structure
PPA
100 °C, 10 min, 70% (2 steps)
intermediate structure