Pinnick-Lindgren Oxidation

Schematic representation of the Pinnick-Lindgren Oxidation.
Mechanism of the Pinnick-Lindgren Oxidation
Mechanism of the Pinnick-Lindgren Oxidation
Sample reactions
intermediate structure
NaClO2, NaH2PO4, 2-Methyl-2-butene
t-BuOH
3.5 h
intermediate structure
intermediate structure
NaClO2, 2-Methyl-2-butene, NaH2PO4
t-BuOH
0 °C to RT, ON, 75% (2 steps)
intermediate structure
intermediate structure
NaClO2, NaH2PO4, 2-Methyl-2-butene
THF, t-BuOH, H2O
RT, 60 min, 80%
intermediate structure
intermediate structure
NaClO2, 2-Methyl-2-butene, NaH2PO4
t-BuOH, H2O
RT, ON
intermediate structure
intermediate structure
NaClO2, 2-Methyl-2-butene, NaH2PO4
t-BuOH, H2O
RT, 12 h, 88% (2 steps)
intermediate structure
intermediate structure
NaClO2, 2-Methyl-2-butene, NaH2PO4
t-BuOH, H2O
RT, 2 h
intermediate structure
intermediate structure
NaClO2, NaH2PO4, 2-Methyl-2-butene
t-BuOH, H2O
56% (2 steps)
intermediate structure
intermediate structure
NaClO2, NaH2PO4, 2-Methyl-2-butene
t-BuOH, H2O
RT, 30 min, 85%
intermediate structure
intermediate structure
NaClO2, NaH2PO4, 2-Methyl-2-butene
t-BuOH, H2O
RT, 30 min, 85%
intermediate structure
intermediate structure
NaClO2, NaH2PO4, 2-Methyl-2-butene
t-BuOH, H2O
0 °C to RT, 70 min
intermediate structure
intermediate structure
NaClO2, NaH2PO4, 2-Methyl-2-butene
t-BuOH, MeCN
0 °C to RT
intermediate structure
intermediate structure
NaClO2, NaH2PO4, 2-Methyl-2-butene
t-BuOH, H2O
RT, 5 h, 70%
intermediate structure