Pinacol Coupling

Schematic representation of the Pinacol Coupling.
Mechanism of the Pinacol Coupling
Mechanism of the Pinacol Coupling
Sample reactions
intermediate structure
(TiCl3)2.2DME, Zn-Cu
DME
70 °C, 60 min, 23%
intermediate structure
intermediate structure
TiCl2, LiAlH4
THF
0 °C to Reflux, 40 min, 43-71%
intermediate structure