Parikh-Doering Oxidation

Schematic representation of the Parikh-Doering Oxidation.
Mechanism of the Parikh-Doering Oxidation
Mechanism of the Parikh-Doering Oxidation
Sample reactions
intermediate structure
Pyr.SO3, Et3N
DMSO
RT, 30 min, 85%
intermediate structure
intermediate structure
Pyr.SO3, Et3N
DMSO
RT, 10 min, 97%
intermediate structure
intermediate structure
Pyr.SO3, DMSO, Et3N
CH2Cl2
0 °C, 90 min, 94% (2 steps)
intermediate structure
intermediate structure
Pyr.SO3, DMSO, Et3N
CH2Cl2
0 °C, 90 min, 100%
intermediate structure
intermediate structure
Pyr.SO3, DMSO, Et3N
CH2Cl2
0 °C, 2 h, 78%
intermediate structure
intermediate structure
Pyr.SO3, DMSO, Et3N
CH2Cl2
5 °C to RT, , 75%
intermediate structure
intermediate structure
Pyr.SO3, DMSO, Et3N
CH2Cl2
0 °C, 30 min, 90%
intermediate structure
intermediate structure
Pyr.SO3, DMSO, Et3N
CH2Cl2
0 °C, 30 min, 93%
intermediate structure
intermediate structure
Pyr.SO3, Et3N
DMSO
RT, 4 h, 70%
intermediate structure
intermediate structure
Pyr.SO3, Et3N
DMSO
RT, 60 min
intermediate structure
intermediate structure
Pyr.SO3, DMSO, i-Pr2NEt
CH2Cl2
0 °C, 30 min
intermediate structure
intermediate structure
Pyr.SO3, DMSO, i-Pr2NEt
CH2Cl2
0 °C, 2 h
intermediate structure