Overman Rearrangement

Mechanism of the Overman Rearrangement

Original publication	J. Am. Chem. Soc.. 1974, 96, 597.
Reviews	Acc. Chem. Res.. 1980, 13, 218. Org. React.. 2005, 66, 1.

Sample reactions

Et3N, (CF3CO)2O, Cl3CCH2OH

CH2Cl2

0 °C to RT, 3.5 h, 87%

Na2CO3

o-Xylene

140 °C, 2.5 h, 58% (2 steps)