Nef Reaction

Schematic representation of the Nef Reaction.
Mechanism of the Nef Reaction
Mechanism of the Nef Reaction
Original publication
Liebigs Ann.. 1894, 280, 263.
Reviews
Chem. Rev.. 1955, 55, 137. Comp. Org. Syn.. 1991, 6, 937. Org. React.. 1990, 38, 655. Tetrahedron. 2004, 60, 1017.
Sample reactions
info
intermediate structure
HCl, NaOEt
EtOH, H2O
0 °C to RT, 2.5 h
intermediate structure
info
intermediate structure
H2O, NaOMe, NH4OAc, TiCl3, NH2OMe.HCl
MeOH
10 to 20 °C, 2 h, 64%
intermediate structure
info
intermediate structure
H2O, HCl, NaOEt
EtOH
10 °C to Reflux, 20 min, 90%
intermediate structure