Meerwein-Ponndorf-Verley Reduction

Mechanism of the Meerwein-Ponndorf-Verley Reduction

Original publication	Liebigs Ann.. 1924, 444, 221. Angew. Chem.. 1926, 39, 138. Bull. Soc. Chim. Fr.. 1925, 37, 537. J. Org. Chem.. 2006, 71, 8516.
Reviews	Chirality. 2002, 14, 759. Curr. Org. Chem.. 2006, 10, 1639. Org. React.. 1944, 2, 178.

Sample reactions

Al, NaOEt

EtOH

Reflux, 2 h, 5%

"(-)-Quinine was selectively cristallized (as a tartrate salt) from the resulting four diastereoisomers."

Al(Oi-Pr)3

i-PrOH

Reflux, 60 min, 60%