Ley-Griffith Oxidation

Schematic representation of the Ley-Griffith Oxidation.

Mechanism of the Ley-Griffith Oxidation

Mechanism of the Ley-Griffith Oxidation

Original publication	J. Chem. Soc., Chem. Commun.. 1987, 0, 1625.
Review

Sample reactions

intermediate structure

NMO, n-Pr4N+ RuO4-

4 Å MS

CH2Cl2

RT, 60 min

intermediate structure

intermediate structure

NMO, n-Pr4N+ RuO4-

4 Å MS

CH2Cl2

RT, 60 min, 86% 2 steps)

intermediate structure

intermediate structure

NMO, n-Pr4N+ RuO4-

4 Å MS

CH2Cl2

RT, 43 h, 98%

intermediate structure

intermediate structure

NMO, n-Pr4N+ RuO4-

4 Å MS

CH2Cl2

94%

intermediate structure

intermediate structure

NMO, n-Pr4N+ RuO4-

4 Å MS

CH2Cl2

RT, 5 h, 84% (3 steps)

intermediate structure

intermediate structure

NMO, n-Pr4N+ RuO4-

CH2Cl2

RT, 15 min, 100%

intermediate structure

intermediate structure

NMO, n-Pr4N+ RuO4-

MeCN

RT, 2 h, 95%

intermediate structure

intermediate structure

NMO, n-Pr4N+ RuO4-

CH2Cl2, MeCN

RT, 2 h, 82%

intermediate structure

intermediate structure

NMO, n-Pr4N+ RuO4-

MeCN

RT, 2 h, 93%

intermediate structure

intermediate structure

NMO, n-Pr4N+ RuO4-

4 Å MS

CH2Cl2

0 °C, 30 min, 92%

intermediate structure

intermediate structure

NMO, n-Pr4N+ RuO4-

4 Å MS

CH2Cl2, MeCN

0 °C to RT, 60 min, 80%

intermediate structure

intermediate structure

NMO, n-Pr4N+ RuO4-

4 Å MS

CH2Cl2

RT, 60 min, 76%

intermediate structure

intermediate structure

NMO, n-Pr4N+ RuO4-

CH2Cl2

RT, 2.5 h, 100%

intermediate structure

intermediate structure

NMO, n-Pr4N+ RuO4-

4 Å MS

CH2Cl2

RT, 30 min, 85%

intermediate structure

intermediate structure

NMO, n-Pr4N+ RuO4-

86%

intermediate structure

intermediate structure

NMO, n-Pr4N+ RuO4-

4 Å MS

CH2Cl2

RT, 60 min

intermediate structure

intermediate structure

NMO, n-Pr4N+ RuO4-

CH2Cl2

0 °C to RT, 20 min

intermediate structure

intermediate structure

NMO, n-Pr4N+ RuO4-

4Å MS

CH2Cl2

RT, 90 min, 91%

intermediate structure

intermediate structure

NMO, n-Pr4N+ RuO4-

4Å MS

MeCN

0 °C to RT, 2.5 h, 80%

intermediate structure

intermediate structure

NMO, n-Pr4N+ RuO4-

4 Å MS

MeCN

RT, 75 min, 76% (3 steps)

intermediate structure

intermediate structure

NMO, n-Pr4N+ RuO4-

4A MS

CH2Cl2

0 °C, 60 min, 75%

intermediate structure

intermediate structure

NMO, n-Pr4N+ RuO4-

4A MS

CH2Cl2

RT, 90 min, 82%

intermediate structure

intermediate structure

NMO, n-Pr4N+ RuO4-

MeCN

0 °C to RT

intermediate structure

intermediate structure

NMO, n-Pr4N+ RuO4-

4 A MS

CH2Cl2

RT, 30 min, 80%

intermediate structure

intermediate structure

NMO, n-Pr4N+ RuO4-

4A MS

CH2Cl2

RT, 20 min, 63%

intermediate structure