Leimgruber-Batcho Indole Synthesis

Schematic representation of the Leimgruber-Batcho Indole Synthesis.
Mechanism of the Leimgruber-Batcho Indole Synthesis
Mechanism of the Leimgruber-Batcho Indole Synthesis
Sample reactions
intermediate structure
Fe, SiO2
PhMe, AcOH
Reflux, 20 min, 71%
intermediate structure
intermediate structure
H2, Pd/C, HCl
MeOH
62%
intermediate structure
intermediate structure
H2, Pd/C
EtOAc, EtOH, AcOH
RT, , 55%
intermediate structure