Knoevenagel Condensation
Mechanism of the Knoevenagel Condensation
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Reviews |
Sample reactions
Et2NH, H2C(CN)2
EtOH
50 to 100 °C, 10 min, 95-98%
Et2NH, H2C(CN)2
EtOH
100 °C, 60 min, 97%
Malonic Acid, PhNH2
EtOH
Reflux, 8 h, 70-75%
"The starting material is an intermediate of the second part of this synthesis."
(CH2NH2)2.2AcOH
PhH
RT, 2 h
NaOMe
MeOH
0 °C, 30 min
NaOMe
MeOH
0 °C, 2 h, 47% (5 steps)
Piperidine
EtOH
Reflux, 60 min, 81%
H2O