Ireland-Claisen Rearrangement

Schematic representation of the Ireland-Claisen Rearrangement.
Mechanism of the Ireland-Claisen Rearrangement
Mechanism of the Ireland-Claisen Rearrangement
Sample reactions
intermediate structure
i-Pr2NLi, TBSCl
THF, HMPA
-78 °C, 2.5 h
intermediate structure
intermediate structure
i-Pr2NLi, TBSCl
THF
-78 °C to Reflux, 4.5 h
intermediate structure
intermediate structure
CHCl3
Reflux, 5 h
intermediate structure