Hofmann Rearrangement

Schematic representation of the Hofmann Rearrangement.
Mechanism of the Hofmann Rearrangement
Mechanism of the Hofmann Rearrangement
Sample reactions
intermediate structure
PhI(O2CCF3)2, Pyr
MeCN
RT, 3 h
intermediate structure
intermediate structure
AllylOH, PhI(OAc)2
DCE
60 °C, 11 h, 88%
intermediate structure
intermediate structure
Pb(OAc)4
t-BuOH
50 °C, 3 h, 70%
intermediate structure