Hofmann-Löffler-Freytag Reaction

Schematic representation of the Hofmann-Löffler-Freytag Reaction.
Mechanism of the Hofmann-Löffler-Freytag Reaction
Mechanism of the Hofmann-Löffler-Freytag Reaction
Sample reactions
intermediate structure
NaOEt
EtOH
Reflux, 10 min, 88%
intermediate structure
intermediate structure
CF3CO2H
0 °C, 50 min
intermediate structure