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Protecting Groups
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Named Reactions
Protecting Groups
Hofmann Elimination
Mechanism of the Hofmann Elimination
Original publication
Liebigs Ann.. 1851, 78, 253.
J. Org. Chem.. 1981, 46, 1959.
Review
Org. React.. 1960, 11, 317.
Sample reactions
info
NaOH
H2O
180 °C, 60 min, 38%
info
Me2SO4
,
NaOH
H2O
Reflux, 2.5 h, 84%
info
Ag2O
H2O
RT to >120 °C, , 80%