Favorskii Rearrangement

Mechanism of the Favorskii Rearrangement

Original publication	J. Russ. Phys. Chem. Soc.. 1894, 26, 590. Org. Synth.. 1959, 39, 37.
Reviews	Curr. Org. Chem.. 2005, 9, 1713. J. Chem. Educ.. 1978, 55, 286. Org. React.. 1960, 11, 261. Russ. Chem. Rev.. 1970, 39, 732.

Sample reactions

KOH

H2O

Reflux, , 95%

KOH

H2O

Reflux, , 55%

NaOH

H2O

Reflux, 5 h

KOH

THF

RT to Reflux, 17 h, 70-85%

KOH

H2O

110 °C, 5 h, 60 - 65%