Corey-Posner, Whitesides-House Reaction

Schematic representation of the Corey-Posner, Whitesides-House Reaction.
Mechanism of the Corey-Posner, Whitesides-House Reaction
Mechanism of the Corey-Posner, Whitesides-House Reaction
Original publication
J. Am. Chem. Soc.. 1967, 89, 3911.
Review
Org. React.. 1975, 22, 253.
Sample reactions
info
intermediate structure
MeI, MeLi, CuSCN
Et2O
-78 to -15 °C, 3.5 h, 72%
intermediate structure
info
intermediate structure
CuI, MeI, MeLi
Et2O
-45 °C to RT, 13 h, 95%
intermediate structure