Brook Rearrangement

Mechanism of the Brook Rearrangement

Original publication	Acc. Chem. Res.. 1974, 7, 77.
Reviews	Acc. Chem. Res.. 1974, 7, 77. Tetrahedron. 2001, 57, 2065.

Sample reactions

TMS2NNa, CuBr.Me2S

NMP

0 to 65 °C, 95 min, 10%

n-BuLi, Tf2O

-100 to -80 °C, 30 min, 74% (2 steps)