Barton Decarboxylation

Mechanism of the Barton Decarboxylation

Original publication	J. Chem. Soc., Chem. Commun.. 1983, 0, 939.
Reviews	Heterocycles. 1989, 28, 951. Tetrahedron. 2009, 65, 3563.

Sample reactions

DMAP, t-BuSH

hν

THF

Reflux, 90 min, 77% (2 steps)

BrCCl3

hν

RT to 90 °C, 65 min, 61% (2 steps)

DMAP, t-BuSH

PhMe

Reflux, 45 min, 82% (2 steps)