Barton Decarboxylation

Schematic representation of the Barton Decarboxylation.
Mechanism of the Barton Decarboxylation
Mechanism of the Barton Decarboxylation
Sample reactions
intermediate structure
t-BuSH, DMAP
THF
Reflux, 90 min, 77% (2 steps)
intermediate structure
intermediate structure
BrCCl3
RT to 90 °C, 65 min, 61% (2 steps)
intermediate structure
intermediate structure
t-BuSH, DMAP
PhMe
Reflux, 45 min, 82% (2 steps)
intermediate structure