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Named reactions

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Protecting Groups

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Search synthesis

Mitsunobu Reaction

Mitsunobu Reaction

Mechanism of the Mitsunobu Reaction

Reference

Original reference Bull. Chem. Soc. Jpn 1967, 40, 2380.
Wikipedia link
Organic chemistry portal link


Sample reactions

This reaction is from the synthesis of Quinine by Gilbert Stork. Show me the full synthesis.

Reactant structure
(PhO)2P(O)N3, Ph3P, DEAD
Reaction arrow head
THF
0 °C, 24 h
95%
Product structure

This reaction is from the synthesis of Colchicine by Martin G. Banwell. Show me the full synthesis.

Reactant structure
Zn(N3)2.2Pyr, DIAD, Ph3P
Reaction arrow head
THF
RT, 38 h
30%
Product structure

This reaction is from the synthesis of Alkaloid 251F by Jeffrey Aubé. Show me the full synthesis.

Reactant structure
Zn(N3)2.2Pyr, DEAD, Ph3P
Reaction arrow head
RT, 12 h
100%
Product structure

This reaction is from the synthesis of Sarain A by Larry E. Overman. Show me the full synthesis.

Reactant structure
TsNHBoc, DEAD, Ph3P
Reaction arrow head
THF
0 °C to RT, 24 h
88%
Product structure

This reaction is from the synthesis of Malayamycin A by Stephen Hanessian. Show me the full synthesis.

Reactant structure
DIAD, Ph3P
Reaction arrow head
THF
91%
Product structure

This reaction is from the synthesis of Dysinosin A by Stephen Hanessian. Show me the full synthesis.

Reactant structure
(PhO)2P(O)N3, DEAD, Ph3P
Reaction arrow head
THF
0 °C to RT, 40 min
82%
Product structure

This reaction is from the synthesis of Dibromophakellstatin by Daniel Romo. Show me the full synthesis.

Reactant structure
DIAD, Ph3P
Reaction arrow head
THF
RT to Reflux, 3 h
Product structure

This reaction is from the synthesis of Aigialomycin D by Joanne E. Harvey. Show me the full synthesis.

Reactant structure + Reactant structure
Ph3P, DIAD
Reaction arrow head
THF
0 °C to RT, 2.5 h
94%
Product structure

This reaction is from the synthesis of Morphine by Barry M. Trost. Show me the full synthesis.

Reactant structure
Reagent structurePh3P, DIAD
Reaction arrow head
Et2O
-20 °C, 5 h
Product structure

This reaction is from the synthesis of Morphine by Kathlyn A. Parker. Show me the full synthesis.

Reactant structure + Reactant structure
n-Bu3P, DEAD
Reaction arrow head
THF
0 °C, 4 h
83%
Product structure

This reaction is from the synthesis of Morphine by Johann Mulzer. Show me the full synthesis.

Reactant structure
Reagent structurePhSO2NHMe, n-Bu3P
Reaction arrow head
81%
Product structure

This reaction is from the synthesis of Stigmatellin A by Dieter Enders. Show me the full synthesis.

Reactant structure
4-Methoxyphenol, DEAD, Ph3P
Reaction arrow head
CH2Cl2
0 °C to RT, 3 d
95%
Product structure

This reaction is from the synthesis of Eudistomin C by Tohru Fukuyama. Show me the full synthesis.

Reactant structure + Reactant structure
Ph3P, DEAD
Reaction arrow head
PhH
5 °C to RT, 15 min
90%
Product structure

This reaction is from the synthesis of Eudistomin C by Tohru Fukuyama. Show me the full synthesis.

Reactant structure + Reactant structure
Ph3P, DEAD
Reaction arrow head
PhH
5 °C to RT, 15 min
100%
Product structure

This reaction is from the synthesis of Retigeranic Acid by Leo A. Paquette. Show me the full synthesis.

Reactant structure
Ph3P, DEAD, ZnBr2
Reaction arrow head
THF
RT
91%
Product structure

This reaction is from the synthesis of Retigeranic Acid by Elias J. Corey. Show me the full synthesis.

Reactant structure
BzOH, Ph3P, DEAD
Reaction arrow head
Et2O
-25 °C, 60 min
Product structure

This reaction is from the synthesis of Oseltamivir by Masakatsu Shibasaki. Show me the full synthesis.

Reactant structure
p-NO2BzOH, Ph3P, DEAD, LiOH, H2O
Reaction arrow head
THF
-20 °C, 3 h
80%
Product structure

This reaction is from the synthesis of Oseltamivir by Masakatsu Shibasaki. Show me the full synthesis.

Reactant structure
Ph3P, DEAD
Reaction arrow head
THF
-20 °C, 75 min
66%
Product structure

This reaction is from the synthesis of Strychnine by Tohru Fukuyama. Show me the full synthesis.

Reactant structure
NsNH2, Ph3P, DEAD
Reaction arrow head
PhMe
RT, 5 min
95%
Product structure

This reaction is from the synthesis of Nupharamine by Isao Shimizu. Show me the full synthesis.

Reactant structure
(PhO)2P(O)N3, DEAD, Ph3P
Reaction arrow head
THF
50%
Product structure

This reaction is from the synthesis of Nupharamine by Toshio Honda. Show me the full synthesis.

Reactant structure
(PhO)2P(O)N3, DEAD, Ph3P
Reaction arrow head
THF
0 °C
88%
Product structure

This reaction is from the synthesis of Nupharamine by Siegfried Blechert. Show me the full synthesis.

Reactant structure
Phthalimide, DEAD, Ph2PMe
Reaction arrow head
THF
0 °C to RT, 60 min
50%
Product structure

This reaction is from the synthesis of Nupharamine by Roderick W. Bates. Show me the full synthesis.

Reactant structure + Reactant structure
DIAD, Ph3P
Reaction arrow head
78%
Product structure

This reaction is from the synthesis of Ziziphine N by Dawei Ma. Show me the full synthesis.

Reactant structure + Reactant structure
DIAD, Ph3P
Reaction arrow head
THF
80 °C, 3 h
54%
Product structure

This reaction is from the synthesis of Phyllantidine by Michael A. Kerr. Show me the full synthesis.

Reactant structure
DIAD, Ph3P
Reaction arrow head
PhH
RT, ON
98%
Product structure
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