Mannich Reaction

This step is from the synthesis of Gelsemine by Larry E. Overman. Show me the full synthesis.

(CF₃CO)₂O

CF₃CO₂H
Reflux, 14 h
67 % (2 steps)

This step is from the synthesis of Sarain A by Larry E. Overman. Show me the full synthesis.

BCl₃, 2,6-Di-tert-butyl-4-methylpyridine

CH₂Cl₂
RT, 15 h
85 %

This step is from the synthesis of Indolizidine 223A by Franklin A. Davis. Show me the full synthesis.

TMS₂NLi

Et₂O
-78 °C, 3 h
78 %

This step is from the synthesis of Indolizidine 223A by Franklin A. Davis. Show me the full synthesis.

TsOH

PhH
RT, 40 h
58 % (3 steps)

This step is from the synthesis of Luciduline by David A. Evans. Show me the full synthesis.

(CH₂O)_n

3-Methyl-1-butanol
Reflux, 20 h

This step is from the synthesis of Taxol by Paul A. Wender. Show me the full synthesis.

Dess-Martin Periodinane, NaHCO₃, H₂CN⁺Me₂ I^-

CH₂Cl₂, Et₃N
RT, ON
97 %

This step is from the synthesis of Ingenol by Isao Kuwajima. Show me the full synthesis.

DMF
100 °C

This step is from the synthesis of Cyanocobalamin by Robert B. Woodward. Show me the full synthesis.

HgO, BF₃^.OEt₂

MeOH

This step is from the synthesis of Ervitsine by Joan Bosch. Show me the full synthesis.

i-PrN(Cy)Li, H₂CN⁺Me₂ I^-

THF
-78 to 0 °C, 8 h
15 %

This step is from the synthesis of Strychnine by Rodrigo B. Andrade. Show me the full synthesis.

CF₃CO₂H

CH₂Cl₂
-78 °C to RT, 5.5 h
78 %

This step is from the synthesis of Strychnine by Martin E. Kuehne. Show me the full synthesis.

t-BuOCl, Et₃N, ZnCl₂

THF
-78 °C to RT, ON

This step is from the synthesis of Strychnine by Martin E. Kuehne. Show me the full synthesis.

THF
-78 °C to RT, 13 h
83 % (2 steps)

This step is from the synthesis of Strychnine by Stephen F. Martin. Show me the full synthesis.

THF
-78 °C to RT, 2 h
79 %

This step is from the synthesis of Strychnine by Stephen F. Martin. Show me the full synthesis.

TMS₂NLi

THF
-15 °C to RT, 3.5 h
26 %

This step is from the synthesis of Nupharamine by Franklin A. Davis. Show me the full synthesis.

2-Butanone, TMS₂NK

Et₂O
-78 °C, 90 min
84 %

This step is from the synthesis of Nupharamine by Franklin A. Davis. Show me the full synthesis.

TsOH

PhH
60 °C, 4 h
74 %

This step is from the synthesis of Azadirachtin by Steven V. Ley. Show me the full synthesis.

H₂CN⁺Me₂ I^-

CH₂Cl₂
35 °C, 48 h