Synarchive logo
Google+ Facebook Twitter RSS Feed
Support this website
Synarchive is free but requires a lot of work. If you enjoy and find it useful, please support us by making a donation.
Named reactions

Get references and more from over 225 named organic chemical reaction

Go to the named reaction index

Protecting Groups

Get the conditions needed to install/remove a wide range of protecting groups.

Go to the protecting groups index

Search synthesis

Mannich Reaction

Mannich Reaction

Mechanism of the Mannich Reaction

Reference

Original reference Archiv Pharm. 1912, 250, 647.
Wikipedia link
Organic chemistry portal link


Sample reactions

This step is from the synthesis of Gelsemine by Larry E. Overman. Show me the full synthesis.

Reactant structure
(CF3CO)2O
Reaction arrow head
CF3CO2H
Reflux, 14 h
67 % (2 steps)
Product structure

This step is from the synthesis of Sarain A by Larry E. Overman. Show me the full synthesis.

Reactant structure
BCl3, 2,6-Di-tert-butyl-4-methylpyridine
Reaction arrow head
CH2Cl2
RT, 15 h
85 %
Product structure

This step is from the synthesis of Indolizidine 223A by Franklin A. Davis. Show me the full synthesis.

Reactant structure + Reactant structure
TMS2NLi
Reaction arrow head
Et2O
-78 °C, 3 h
78 %
Product structure

This step is from the synthesis of Indolizidine 223A by Franklin A. Davis. Show me the full synthesis.

Reactant structure
TsOH
Reaction arrow head
PhH
RT, 40 h
58 % (3 steps)
Product structure

This step is from the synthesis of Luciduline by David A. Evans. Show me the full synthesis.

Reactant structure
(CH2O)n
Reaction arrow head
3-Methyl-1-butanol
Reflux, 20 h
Product structure

This step is from the synthesis of Taxol by Paul A. Wender. Show me the full synthesis.

Reactant structure
Dess-Martin Periodinane, NaHCO3, H2CN+Me2 I-, Et3N
Reaction arrow head
CH2Cl2
RT, ON
97 %
Product structure

This step is from the synthesis of Ingenol by Isao Kuwajima. Show me the full synthesis.

Reactant structure + Reactant structure
Reaction arrow head
DMF
100 °C
Product structure

This step is from the synthesis of Cyanocobalamin by Robert B. Woodward. Show me the full synthesis.

Reactant structure
HgO, BF3.OEt2
Reaction arrow head
MeOH
Product structure

This step is from the synthesis of Ervitsine by Joan Bosch. Show me the full synthesis.

Reactant structure + Reactant structure
i-PrN(Cy)Li, H2CN+Me2 I-
Reaction arrow head
THF
-78 to 0 °C, 8 h
15 %
Product structure

This step is from the synthesis of Strychnine by Rodrigo B. Andrade. Show me the full synthesis.

Reactant structure + Reactant structure + Reactant structure
CF3CO2H
Reaction arrow head
CH2Cl2
-78 °C to RT, 5.5 h
78 %
Product structure

This step is from the synthesis of Strychnine by Martin E. Kuehne. Show me the full synthesis.

Reactant structure + Reactant structure
t-BuOCl, Et3N, ZnCl2
Reaction arrow head
THF
-78 °C to RT, ON
Product structure

This step is from the synthesis of Strychnine by Martin E. Kuehne. Show me the full synthesis.

Reactant structure + Reactant structure
Reaction arrow head
THF
-78 °C to RT, 13 h
83 % (2 steps)
Product structure

This step is from the synthesis of Strychnine by Stephen F. Martin. Show me the full synthesis.

Reactant structure + Reactant structure + Reactant structure
Reaction arrow head
THF
-78 °C to RT, 2 h
79 %
Product structure

This step is from the synthesis of Strychnine by Stephen F. Martin. Show me the full synthesis.

Reactant structure
TMS2NLi
Reaction arrow head
THF
-15 °C to RT, 3.5 h
26 %
Product structure

This step is from the synthesis of Nupharamine by Franklin A. Davis. Show me the full synthesis.

Reactant structure
2-Butanone, TMS2NK
Reaction arrow head
Et2O
-78 °C, 90 min
84 %
Product structure

This step is from the synthesis of Nupharamine by Franklin A. Davis. Show me the full synthesis.

Reactant structure
TsOH
Reaction arrow head
PhH
60 °C, 4 h
74 %
Product structure

This step is from the synthesis of Azadirachtin by Steven V. Ley. Show me the full synthesis.

Reactant structure
H2CN+Me2 I-
Reaction arrow head
CH2Cl2
35 °C, 48 h
Product structure
homepage - authors - molecules - named reactions - protecting groups - advanced search - contact
© 2011-2014 SynArchive