Horner-Wadsworth-Emmons Reaction

This step is from the synthesis of Quinine by Eric N. Jacobsen. Show me the full synthesis.

n-BuLi

THF
-78 to 0 °C, 2 h
84 %

This step is from the synthesis of Quinine by Yuichi Kobayashi. Show me the full synthesis.

NaH

THF
RT
82 %

This step is from the synthesis of Prostaglandin F2α by Elias J. Corey. Show me the full synthesis.

NaH

DME
RT, 60 min
70 % (2 steps)

This step is from the synthesis of U-106305 by André B. Charette. Show me the full synthesis.

(EtO)₂P(O)CH₂CO₂Et, NaH

THF
0 °C to RT, 12.5 h
49 % (2 steps)

This step is from the synthesis of U-106305 by André B. Charette. Show me the full synthesis.

(EtO)₂P(O)CH₂CO₂Et, NaH

THF
0 °C to RT, 12.5 h
41 % (2 steps)

This step is from the synthesis of U-106305 by André B. Charette. Show me the full synthesis.

NaH

DME
0 °C to RT, 5 h
80 %

This step is from the synthesis of Elailoide by David A. Evans. Show me the full synthesis.

TMS₂NLi

THF
-78 °C, 12 h
85 %

This step is from the synthesis of Ingenol by Isao Kuwajima. Show me the full synthesis.

n-BuLi

THF, Et₂O
-98 °C to RT, 3 h
85 %

This step is from the synthesis of Epolactaene by Yujiro Hayashi. Show me the full synthesis.

NaH

THF
0 °C to RT, 60 min
96 %

This step is from the synthesis of Epolactaene by Yujiro Hayashi. Show me the full synthesis.

n-BuLi

DME
0 °C to RT, 40 min
100 %

This step is from the synthesis of Stigmatellin A by Dieter Enders. Show me the full synthesis.

NaH

THF
-78 °C to RT, ON
71 %

This step is from the synthesis of Stigmatellin A by Dieter Enders. Show me the full synthesis.

i-Pr₂NLi

THF
-78 °C to RT, ON
77 % (2 steps)

This step is from the synthesis of Doliculide by Arun K. Ghosh. Show me the full synthesis.

NaH, (EtO)₂P(O)CH₂CO₂Et

THF
0 °C to RT, 4 h
84 %

This step is from the synthesis of Doliculide by Arun K. Ghosh. Show me the full synthesis.

NaH, (EtO)₂P(O)CH₂CO₂Et

THF
0 °C to RT, 4 h
80 % (2 steps)

This step is from the synthesis of Doliculide by Arun K. Ghosh. Show me the full synthesis.

NaH, (EtO)₂P(O)CH₂CO₂Et

THF
0 °C to RT, 4 h
60 % (2 steps)

This step is from the synthesis of Pallidol by Scott A. Snyder. Show me the full synthesis.

KOt-Bu

THF
-78 °C to RT, 13.5 h
98 %

This step is from the synthesis of Ampelopsin F by Scott A. Snyder. Show me the full synthesis.

KOt-Bu

THF
-78 °C to RT, 13.5 h
98 %

This step is from the synthesis of Retigeranic Acid by Tomas Hudlicky. Show me the full synthesis.

i-Pr₂NLi, HMPA

THF
-78 to 0 °C, 60 min

This step is from the synthesis of Strychnine by Albert Padwa. Show me the full synthesis.

Ph₂P(O)CH₂OMe, i-Pr₂NLi

THF
0 °C to RT, 25 h
72 %

This step is from the synthesis of Strychnine by Philip Magnus. Show me the full synthesis.

(EtO)₂P(O)CH₂CN, TMS₂NK

THF
RT, 42 h
43 %

This step is from the synthesis of Strychnine by Martin E. Kuehne. Show me the full synthesis.

(EtO)₂P(O)CH₂CO₂Me, TMS₂NK

THF
0 °C to RT, 8.5 h
64 %

This step is from the synthesis of Strychnine by Martin E. Kuehne. Show me the full synthesis.

(EtO)₂P(O)CH₂CO₂Me, TMS₂NK

THF
RT, 2.5 h
39 %

This step is from the synthesis of Strychnine by David W. C. MacMillan. Show me the full synthesis.

(EtO)₂P(O)CH₂SeMe, TMS₂NK, 18-Crown-6

THF
-78 °C to RT, 90 min
81 %

This step is from the synthesis of Nupharamine by Isao Shimizu. Show me the full synthesis.

NaH

THF
0 °C
87 %

This step is from the synthesis of Nupharamine by Roderick W. Bates. Show me the full synthesis.

Ba(OH)₂

THF, H₂O
87 % (2 steps)

This step is from the synthesis of Azadirachtin by Steven V. Ley. Show me the full synthesis.

LiCl, i-Pr₂NEt

DMF
RT, 44 h
34 %

This step is from the synthesis of Epibatidine by David A. Evans. Show me the full synthesis.

i-Pr₂NEt, LiCl

MeCN
RT, 60 min
81 %

This step is from the synthesis of Hirsutene by Tarun K. Sarkar. Show me the full synthesis.

(EtO)₂P(O)CH₂CO₂Et, NaH

DME
RT, 3 h
76 %

This step is from the synthesis of Decarestrictine D by Ronaldo A. Pilli. Show me the full synthesis.

(EtO)₂P(O)CH₂CO₂Et, NaH

THF
0 °C
70 %