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Named reactions

Get references and more from over 229 named organic chemical reaction

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Protecting Groups

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Search synthesis

Grignard Reaction

Grignard Reaction

Mechanism of the Grignard Reaction

Reference

Original reference Compt. Rend. 1900, 130, 1322.
http://gallica.bnf.fr/ark:/12148/bpt6k3086n.image.r=Comptes+rendus+hebdomadaires+des+sťances+de+l.f1322.langFR
Wikipedia link
Organic chemistry portal link


Sample reactions

This reaction is from the synthesis of Erythromycin A by Pierre Deslongchamps. Show me the full synthesis.

Reactant structure
MeMgBr
Reaction arrow head
Et2O
-78 °C, 60 min
63%
Product structure

This reaction is from the synthesis of Aflatoxin B2 by Elias J. Corey. Show me the full synthesis.

Reactant structure
MeMgBr
Reaction arrow head
THF
-20 °C, 2 h
Product structure

This reaction is from the synthesis of Penitrem D by Amos B. Smith, III. Show me the full synthesis.

Reactant structure
MeMgBr
Reaction arrow head
PhH, Et2O
0 °C to RT, 90 min
Product structure

This reaction is from the synthesis of Sarain A by Larry E. Overman. Show me the full synthesis.

Reactant structure + Reactant structure
Reaction arrow head
THF, Et2O
-78 to -10 °C, 80 min
Product structure

This reaction is from the synthesis of Sarain A by Larry E. Overman. Show me the full synthesis.

Reactant structure + Reactant structure
Reaction arrow head
THF
-15 °C, 60 min
68%
Product structure

This reaction is from the synthesis of Cholesterol by Robert B. Woodward. Show me the full synthesis.

Reactant structure
MeMgBr
Reaction arrow head
PhH, Et2O
-18 °C, 3 h
Product structure

This reaction is from the synthesis of Cholesterol by Robert B. Woodward. Show me the full synthesis.

Reactant structure + Reactant structure
Reaction arrow head
PhH, Et2O
RT, 60 min
Product structure

This reaction is from the synthesis of Zaragozic Acid C by David A. Evans. Show me the full synthesis.

Reactant structure
VinylMgBr
Reaction arrow head
CH2Cl2, THF
-78 °C, 10 h
76%
Product structure

This reaction is from the synthesis of Preussin by Won-Hun Ham. Show me the full synthesis.

Reactant structure
VinylMgBr
Reaction arrow head
THF
0 °C
70% (2 steps)
Product structure

This reaction is from the synthesis of Luciduline by David A. Evans. Show me the full synthesis.

Reactant structure
IsopropenylMgBr
Reaction arrow head
Product structure

This reaction is from the synthesis of Taxol by Robert A. Holton. Show me the full synthesis.

Reactant structure
MeMgBr
Reaction arrow head
CH2Cl2
-65 to -48 °C, 16.5 h
95%
Product structure

This reaction is from the synthesis of Taxol by Paul A. Wender. Show me the full synthesis.

Reactant structure
AllylMgBr, ZnCl2
Reaction arrow head
THF
-78 °C, 17 min
89%
Product structure

This reaction is from the synthesis of Taxol by Isao Kuwajima. Show me the full synthesis.

Reactant structure + Reactant structure
t-BuMgCl
Reaction arrow head
THF
-78 °C, 90 min
68%
Product structure

This reaction is from the synthesis of Taxol by Teruaki Mukaiyama. Show me the full synthesis.

Reactant structure
MeMgBr
Reaction arrow head
Et2O
-78 °C, 100 min
99%
Product structure

This reaction is from the synthesis of Murrayazoline by Noritaka Chida. Show me the full synthesis.

Reactant structure
MeMgBr
Reaction arrow head
Et2O
0 °C, 60 min
77%
Product structure

This reaction is from the synthesis of Buckminsterfullerene by Lawrence T. Scott. Show me the full synthesis.

Reactant structure
Mg, MeCHO
Reaction arrow head
Et2O
97%
Product structure

This reaction is from the synthesis of Reserpine by Stephen Hanessian. Show me the full synthesis.

Reactant structure
VinylMgBr
Reaction arrow head
THF
-78 °C, 2 h
90%
Product structure

This reaction is from the synthesis of Longifolene by John E. McMurry. Show me the full synthesis.

Reactant structure
MeMgI
Reaction arrow head
Et2O
RT, 4.5 h
Product structure

This reaction is from the synthesis of Pactamycin by Stephen Hanessian. Show me the full synthesis.

Reactant structure
MeMgBr
Reaction arrow head
Et2O
0 °C, 60 min
87% (2 steps)
Product structure

This reaction is from the synthesis of Pactamycin by Stephen Hanessian. Show me the full synthesis.

Reactant structure
MeMgBr
Reaction arrow head
THF
-78 °C, 3 h
91%
Product structure

This reaction is from the synthesis of Cylindrospermopsin by Barry B. Snider. Show me the full synthesis.

Reactant structure + Reactant structure
EtMgBr
Reaction arrow head
THF
0 °C to RT, 4 h
69%
Product structure

This reaction is from the synthesis of Retigeranic Acid by Elias J. Corey. Show me the full synthesis.

Reactant structure
VinylMgBr
Reaction arrow head
Et2O
0 °C
97%
Product structure

This reaction is from the synthesis of Asteltoxin by Stuart L. Schreiber. Show me the full synthesis.

Reactant structure
EtMgBr
Reaction arrow head
THF
RT, 48 h
Product structure

This reaction is from the synthesis of Illudinine by Robert B. Woodward. Show me the full synthesis.

Reactant structure
Mg, Br(CH2)2Br, ClCO2Me
Reaction arrow head
THF
RT to Reflux, 5 h
98%
Product structure

This reaction is from the synthesis of Nupharamine by Roderick W. Bates. Show me the full synthesis.

Reactant structure
MeMgBr
Reaction arrow head
Product structure

This reaction is from the synthesis of Hirsutene by Tomas Hudlicky. Show me the full synthesis.

Reactant structure
VinylMgBr
Reaction arrow head
THF
0 °C to RT, 3 h
90% (2 steps)
Product structure

This reaction is from the synthesis of Hirsutene by Paul A. Wender. Show me the full synthesis.

Reactant structure + Reactant structure
Mg, Ac2O, DMAP
Reaction arrow head
Et2O
79%
Product structure

This reaction is from the synthesis of Azadirachtin by Steven V. Ley. Show me the full synthesis.

Reactant structure
AllylMgCl
Reaction arrow head
THF
-78 °C, 30 min
85% (2 steps)
Product structure

This reaction is from the synthesis of Azadirachtin by Steven V. Ley. Show me the full synthesis.

Reactant structure
i-PrMgBr, (CH2O)n
Reaction arrow head
THF
45 °C, 5.5 h
89% (α), 78 % (β)
Product structure

This reaction is from the synthesis of Epibatidine by Alan Armstrong. Show me the full synthesis.

Reactant structure
VinylMgBr
Reaction arrow head
Et2O
-30 °C to RT, 10 min
56%
Product structure

This reaction is from the synthesis of Ferruginol by Frederick E. King. Show me the full synthesis.

Reactant structure
MeMgI
Reaction arrow head
Et2O
Reflux, 60 min
Product structure

This reaction is from the synthesis of Capnellene by Leo A. Paquette. Show me the full synthesis.

Reactant structure
VinylMgBr
Reaction arrow head
THF
10 °C to RT, 4.5 h
46% (2 steps)
Product structure

This reaction is from the synthesis of Phyllantidine by Michael A. Kerr. Show me the full synthesis.

Reactant structure
VinylMgBr
Reaction arrow head
THF
0 °C, 3 h
76%
Product structure

This reaction is from the synthesis of Marinopyrrole B by Derrick L. J. Clive. Show me the full synthesis.

Reactant structure + Reactant structure
Reaction arrow head
THF
0 °C, 4 h
Product structure
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