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Named reactions

Get references and more from over 225 named organic chemical reaction

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Protecting Groups

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Curtius Rearrangement

Curtius Rearrangement

Mechanism of the Curtius Rearrangement

Reference

Original reference Ber. Dtsch. Chem. Ges. 1890, 23, 3023.
Wikipedia link
Organic chemistry portal link


Sample reactions

This reaction is from the synthesis of Colchicine by David A. Evans. Show me the full synthesis.

Reactant structure
(PhO)2P(O)N3, Et3N
Reaction arrow head
t-BuOH
Reflux, 17 h
54 %
Product structure

This reaction is from the synthesis of Gelsemine by Larry E. Overman. Show me the full synthesis.

Reactant structure
(PhO)2P(O)N3, (4-MeOPh)CH2OH
Reaction arrow head
PhMe, Et3N
Reflux, 12 h
72 %
Product structure

This reaction is from the synthesis of Saxitoxin by Yoshi Kishi. Show me the full synthesis.

Reactant structure
Reaction arrow head
PhH
90 °C
Product structure

This reaction is from the synthesis of Triquinacene by Robert B. Woodward. Show me the full synthesis.

Reactant structure
NaN3
Reaction arrow head
PhMe
Product structure

This reaction is from the synthesis of Oseltamivir by Ulrich Zutter. Show me the full synthesis.

Reactant structure
(PhO)2P(O)N3, Et3N
Reaction arrow head
CH2Cl2
40 °C, 16 h
78 %
Product structure

This reaction is from the synthesis of Oseltamivir by Yujiro Hayashi. Show me the full synthesis.

Reactant structure
Ac2O
Reaction arrow head
AcOH
RT, 49 h
Product structure

This reaction is from the synthesis of Streptonigrone by Dale L. Boger. Show me the full synthesis.

Reactant structure
(PhO)2P(O)N3, Et3N
Reaction arrow head
PhH
RT to Reflux, 7.5 h
84 %
Product structure

This reaction is from the synthesis of Streptonigrone by Marco A. Ciufolini. Show me the full synthesis.

Reactant structure
(PhO)2P(O)N3, Et3N
Reaction arrow head
THF
Reflux, 15 h
Product structure

This reaction is from the synthesis of Methoxatin by Steven M. Weinreb. Show me the full synthesis.

Reactant structure
ClCO2Et, Et3N, NaN3
Reaction arrow head
PhMe
Reflux
Product structure
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