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Named reactions

Get references and more from over 225 named organic chemical reaction

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Protecting Groups

Get the conditions needed to install/remove a wide range of protecting groups.

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Search synthesis

Cope Rearrangement

Cope Rearrangement

Mechanism of the Cope Rearrangement

Reference

Original reference J. Am. Chem. Soc. 1940, 62, 441.
Wikipedia link
Organic chemistry portal link


Sample reactions

This reaction is from the synthesis of Strychnine by Larry E. Overman. Show me the full synthesis.

Reactant structure
(CH2O)n, Na2SO4
Reaction arrow head
MeCN
80 °C
98 %
Product structure

This reaction is from the synthesis of Gelsemine by Larry E. Overman. Show me the full synthesis.

Reactant structure
KH, 18-Crown-6, 2,6-Di-tert-butyl-4-methylpyridine, ClCO2Me
Reaction arrow head
THF
-78 °C to RT, 2.5 h
81 %
Product structure

This reaction is from the synthesis of Luciduline by David A. Evans. Show me the full synthesis.

Reactant structure
Sealed tube
Reaction arrow head
250 °C, 4 h
Product structure

This reaction is from the synthesis of Okilactomycin by Amos B. Smith, III. Show me the full synthesis.

Reactant structure
KH, 18-Crown-6, Me2SO4
Reaction arrow head
THF
0 °C to RT, 22 h
96 %
Product structure

This reaction is from the synthesis of Hirsutene by Shigeo Nozoe. Show me the full synthesis.

Reactant structure
Reaction arrow head
240 °C
83 % (2 steps)
Product structure

This reaction is from the synthesis of Glycyrol by Hak Sung Kim. Show me the full synthesis.

Reactant structure
Reaction arrow head
PhNEt2
Reflux, 60 min
64 %
Product structure
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