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Named reactions

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Search synthesis

Claisen Condensation

Claisen Condensation

Mechanism of the Claisen Condensation

Reference

Original reference Ber. Dtsch. Chem. Ges. 1887, 20, 651.
Wikipedia link
Organic chemistry portal link


Sample reactions

This reaction is from the synthesis of Quinine by Robert B. Woodward. Show me the full synthesis.

Reactant structure + Reactant structure
NaOEt
Reaction arrow head
82 °C, 14 h
63 %
Product structure

This reaction is from the synthesis of Strychnine by Larry E. Overman. Show me the full synthesis.

Reactant structure
i-Pr2NLi, MeO2CCN
Reaction arrow head
THF
-78 °C
Product structure

This reaction is from the synthesis of Pentacycloanammoxic Acid by Elias J. Corey. Show me the full synthesis.

Reactant structure
HCO2Et, NaOMe
Reaction arrow head
PhH
RT, 12 h
Product structure

This reaction is from the synthesis of Penitrem D by Amos B. Smith, III. Show me the full synthesis.

Reactant structure
NaH, HCO2Et
Reaction arrow head
THF
0 °C to RT, 3 h
Product structure

This reaction is from the synthesis of Cholesterol by Robert B. Woodward. Show me the full synthesis.

Reactant structure
HCO2Et, NaOMe
Reaction arrow head
PhH
RT, 30 min
94 %
Product structure

This reaction is from the synthesis of Cholesterol by Robert B. Woodward. Show me the full synthesis.

Reactant structure
HCO2Et, NaOMe
Reaction arrow head
PhH
RT, ON
Product structure

This reaction is from the synthesis of Melithiazole C by Janine Cossy. Show me the full synthesis.

Reactant structure
CDI, MeOAc, i-Pr2NLi
Reaction arrow head
THF
-78 to 0 °C, 4 h
72 % (2 steps)
Product structure

This reaction is from the synthesis of Dibromophakellstatin by Daniel Romo. Show me the full synthesis.

Reactant structure
TMS2NK, ClCO2Bn
Reaction arrow head
THF
-78 °C, 6 h
70 %
Product structure

This reaction is from the synthesis of Ingenol by Jeffrey D. Winkler. Show me the full synthesis.

Reactant structure
i-Pr2NLi, MeO2CCN
Reaction arrow head
THF, HMPA
-78 °C, 90 min
89 %
Product structure

This reaction is from the synthesis of Ingenol by Jeffrey D. Winkler. Show me the full synthesis.

Reactant structure + Reactant structure
i-Pr2NLi
Reaction arrow head
Et2O
-78 °C, 2 h
Product structure

This reaction is from the synthesis of Gymnomitrol by Robert M. Coates. Show me the full synthesis.

Reactant structure
NaH, HCO2Et
Reaction arrow head
THF
RT, 14 h
83 %
Product structure

This reaction is from the synthesis of Morphine by James D. White. Show me the full synthesis.

Reactant structure
KH, HCO2Me
Reaction arrow head
THF
RT, 8 h
Product structure

This reaction is from the synthesis of Epolactaene by Yujiro Hayashi. Show me the full synthesis.

Reactant structure
n-BuLi, MeCN
Reaction arrow head
THF
-88 to -78 °C, 60 min
93 %
Product structure

This reaction is from the synthesis of Dodecahedrane by Horst Prinzbach. Show me the full synthesis.

Reactant structure + Reactant structure
NaH, HCO2Me
Reaction arrow head
THF, MeOH
RT to 40 °C, 20 h
100 %
Product structure + Product structure

This reaction is from the synthesis of Morphine by Johann Mulzer. Show me the full synthesis.

Reactant structure
HCO2Me, NaOMe
Reaction arrow head
PhH
95 %
Product structure

This reaction is from the synthesis of Strychnine by Masakatsu Shibasaki. Show me the full synthesis.

Reactant structure + Reactant structure
i-Pr2NLi
Reaction arrow head
THF
-78 °C, 19 h
72 %
Product structure

This reaction is from the synthesis of Strychnine by Martin E. Kuehne. Show me the full synthesis.

Reactant structure
TMS2NLi
Reaction arrow head
THF
Reflux, 30 min
Product structure

This reaction is from the synthesis of Panacene by Ken S. Feldman. Show me the full synthesis.

Reactant structure
NaH
Reaction arrow head
PhH
81 % (2 steps)
Product structure

This reaction is from the synthesis of Nupharamine by Jerzy T. Wróbel. Show me the full synthesis.

Reactant structure
Na, HCO2Et
Reaction arrow head
Et2O
100 %
Product structure

This reaction is from the synthesis of Bikaverin by Derek H. R. Barton. Show me the full synthesis.

Reactant structure
(CO2Et)2, NaOEt
Reaction arrow head
PhH
RT, 4 h
40 %
Product structure

This reaction is from the synthesis of Streptonigrone by Dale L. Boger. Show me the full synthesis.

Reactant structure
i-Pr2NLi, EtOAc
Reaction arrow head
THF, Hexane(s)
-78 °C to RT, 55 min
71 %
Product structure

This reaction is from the synthesis of Streptonigrone by Marco A. Ciufolini. Show me the full synthesis.

Reactant structure
NaH, EtOAc
Reaction arrow head
PhMe
110 °C, 15 h
Product structure

This reaction is from the synthesis of Coccinelline by Robert V. Stevens. Show me the full synthesis.

Reactant structure
NaH
Reaction arrow head
DME
Reflux, 17 h
Product structure

This reaction is from the synthesis of Alkaloid GB 13 by Lewis N. Mander. Show me the full synthesis.

Reactant structure
HCO2Me, NaH
Reaction arrow head
THF
0 °C, 17 h
Product structure

This reaction is from the synthesis of Promothiocin A by Christopher J. Moody. Show me the full synthesis.

Reactant structure + Reactant structure
ClCO2Et, Et3N
Reaction arrow head
THF
0 °C to RT, ON
77 %
Product structure
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