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Named reactions

Get references and more from over 229 named organic chemical reaction

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Protecting Groups

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Search synthesis

Appel Reaction

Appel Reaction

Mechanism of the Appel Reaction

Reference

Original reference Angew. Chem. Int. Ed. 1975, 14, 801.
Wikipedia link
Organic chemistry portal link


Sample reactions

This reaction is from the synthesis of Quinine by Yuichi Kobayashi. Show me the full synthesis.

Reactant structure
I2, Ph3P, Imidazole
Reaction arrow head
88%
Product structure

This reaction is from the synthesis of Ingenol by John L. Wood. Show me the full synthesis.

Reactant structure
I2, Ph3P, Imidazole
Reaction arrow head
THF
0 °C, 3 h
Product structure

This reaction is from the synthesis of Ingenol by Jeffrey D. Winkler. Show me the full synthesis.

Reactant structure
Ph3P, C2Cl6
Reaction arrow head
CH2Cl2, Et2O
0 °C, 60 min
93%
Product structure

This reaction is from the synthesis of Pseudolaric Acid B by Barry M. Trost. Show me the full synthesis.

Reactant structure
Ph3P, I2, Imidazole
Reaction arrow head
PhMe
RT, 60 min
90%
Product structure

This reaction is from the synthesis of Doliculide by Arun K. Ghosh. Show me the full synthesis.

Reactant structure
Ph3P, I2, Imidazole
Reaction arrow head
CH2Cl2
RT, 60 min
80%
Product structure

This reaction is from the synthesis of Doliculide by Arun K. Ghosh. Show me the full synthesis.

Reactant structure
Ph3P, I2, Imidazole
Reaction arrow head
CH2Cl2
RT, 60 min
Product structure

This reaction is from the synthesis of Caribenol A by Zhen Yang. Show me the full synthesis.

Reactant structure
I2, Ph3P, Imidazole
Reaction arrow head
MeCN, Et2O
0 °C to RT, 70 min
89%
Product structure

This reaction is from the synthesis of Caribenol A by Zhen Yang. Show me the full synthesis.

Reactant structure
I2, Ph3P, Imidazole
Reaction arrow head
MeCN, Et2O
0 °C to RT, 2 h
85%
Product structure

This reaction is from the synthesis of Maritimol by Pierre Deslongchamps. Show me the full synthesis.

Reactant structure
Cl3CC(O)CCl3, Ph3P
Reaction arrow head
CH2Cl2
-78 to 0 °C, 15 min
94%
Product structure

This reaction is from the synthesis of Hirsutene by Steven V. Ley. Show me the full synthesis.

Reactant structure
Br2, Ph3P
Reaction arrow head
PhH, DMF
RT, 4 h
59%
Product structure
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