Aldol Addition

This step is from the synthesis of Colchicine by David A. Evans. Show me the full synthesis.

i-Pr₂NLi, (CO₂H)₂

THF, THF
-70 °C, 2 h

This step is from the synthesis of Ryanodol by Pierre Deslongchamps. Show me the full synthesis.

NaOH

THF, H₂O
RT

This step is from the synthesis of Ryanodol by Pierre Deslongchamps. Show me the full synthesis.

NaOH

THF
RT

This step is from the synthesis of Ryanodol by Pierre Deslongchamps. Show me the full synthesis.

O₃, TsOH, Me₂S

EtOAc
90 %

This step is from the synthesis of Erythromycin A by Robert B. Woodward. Show me the full synthesis.

D-Proline

MeCN
RT

This step is from the synthesis of Erythromycin A by Robert B. Woodward. Show me the full synthesis.

MesLi

THF
-50 °C

This step is from the synthesis of Erythromycin A by Robert B. Woodward. Show me the full synthesis.

EtCOSt-Bu, i-Pr₂NLi

THF
-110 °C
85 %

This step is from the synthesis of Erythromycin A by Pierre Deslongchamps. Show me the full synthesis.

EtCO₂Me, Cp₂ZrCl₂, i-Pr₂NLi

THF
-78 °C to RT, 2 h
60 %

This step is from the synthesis of Ginkgolide B by Elias J. Corey. Show me the full synthesis.

EtCO₂t-Bu, i-Pr₂NLi

THF, HMPA
-78 to -30 °C, 12 h
60 %

This step is from the synthesis of Penitrem D by Amos B. Smith, III. Show me the full synthesis.

MeLi, MgBr₂^.OEt₂

Et₂O
-5 °C to RT, 70 min
65 %

This step is from the synthesis of Tetrodotoxin by Justin Du Bois. Show me the full synthesis.

NaOAc

THF

This step is from the synthesis of Taxol by Robert A. Holton. Show me the full synthesis.

i-Pr₂NMgBr

THF
-23 °C to RT, 2.5 h

This step is from the synthesis of Taxol by Paul A. Wender. Show me the full synthesis.

MeLi, CuI

Et₂O
-78 °C to RT, ON
97 %

This step is from the synthesis of Taxol by Paul A. Wender. Show me the full synthesis.

ClCO₂CH₂CCl₃, DMAP

CH₂Cl₂
RT, 42 h
62 %

This step is from the synthesis of Taxol by Teruaki Mukaiyama. Show me the full synthesis.

i-Pr₂NLi, i-PrCO₂Me

Et₂O
-78 °C
65 %

This step is from the synthesis of Taxol by Teruaki Mukaiyama. Show me the full synthesis.

NaOMe

MeOH, THF
0 °C
90 %

This step is from the synthesis of Elailoide by David A. Evans. Show me the full synthesis.

PhBCl₂, i-Pr₂NEt

CH₂Cl₂
-78 to 0 °C, 2.5 h
66 %

This step is from the synthesis of Fredericamycin A by Dale L. Boger. Show me the full synthesis.

(CF₃CO)₂O, DMSO, DBU

CH₂Cl₂
-78 °C to RT, 21 h

This step is from the synthesis of Cortistatin A by Matthew D. Shair. Show me the full synthesis.

NaOMe

MeOH
70 °C, 2 h
49 % (2 steps)

This step is from the synthesis of Ingenol by Isao Kuwajima. Show me the full synthesis.

TMS₂NLi, MeCHO, ZnBr₂

THF, Et₂O
-78 to 0 °C, 2 h
71 %

This step is from the synthesis of Ingenol by Isao Kuwajima. Show me the full synthesis.

i-Pr₂NLi, MeCO₂t-Bu, LiBr

Et₂O
-78 °C, 90 min
91 %

This step is from the synthesis of Gymnomitrol by Leo A. Paquette. Show me the full synthesis.

KOH

MeOH
2.5 d
26 %

This step is from the synthesis of Grandisine D by Osamu Tamura. Show me the full synthesis.

n-Bu₂BOTf, i-Pr₂NEt

CH₂Cl₂
-78 °C to RT, 2 h
100 %

This step is from the synthesis of Epolactaene by Yujiro Hayashi. Show me the full synthesis.

MeCHO, i-Pr₂NLi

THF, HMPA
-78 °C, 4.5 h
96 %

This step is from the synthesis of Stigmatellin A by Dieter Enders. Show me the full synthesis.

TiCl₄, i-Pr₂NEt

CH₂Cl₂
-78 °C to RT, 3.5 h
64 %

This step is from the synthesis of Laurenene by Leo A. Paquette. Show me the full synthesis.

HCl

Acetone, H₂O
RT, 3 d
79 % (2 steps)

This step is from the synthesis of Laurenene by Leo A. Paquette. Show me the full synthesis.

HCl

THF, H₂O
RT
71 %

This step is from the synthesis of Longifolene by John E. McMurry. Show me the full synthesis.

Me₂CuLi

Et₂O
-20 °C, 40 min
96 %

This step is from the synthesis of Longifolene by Alex G. Fallis. Show me the full synthesis.

i-Pr₂NLi, CdCl₂

THF
-40 to 0 °C, 2.5 h
73 %

This step is from the synthesis of Triquinacene by Pierre Deslongchamps. Show me the full synthesis.

HCl

Acetone, H₂O
RT, 60 min

This step is from the synthesis of Triquinacene by James M. Cook. Show me the full synthesis.

HCl

THF, H₂O
RT, 7 d
86 %

This step is from the synthesis of Quadrone by Samuel J. Danishefsky. Show me the full synthesis.

i-Pr₂NLi, CH₂O

THF
-23 °C, 80 min
60 %

This step is from the synthesis of Pactamycin by Stephen Hanessian. Show me the full synthesis.

TMS₂NLi

THF
-78 °C, 55 min

This step is from the synthesis of Pactamycin by Stephen Hanessian. Show me the full synthesis.

TiCl₄, i-Pr₂NEt, TMSCl

CH₂Cl₂
0 °C, 20 min
85 %

This step is from the synthesis of Retigeranic Acid by Leo A. Paquette. Show me the full synthesis.

HCl

Acetone, H₂O
RT, 3 d
72 % (2 steps)

This step is from the synthesis of Retigeranic Acid by Paul A. Wender. Show me the full synthesis.

i-Pr₂NLi

THF
-78 to 50 °C, 5 h

This step is from the synthesis of Asteltoxin by Stuart L. Schreiber. Show me the full synthesis.

i-Pr₂NLi, HMPA

THF
-78 °C, 20 min
80 %

This step is from the synthesis of Strychnine by Rodrigo B. Andrade. Show me the full synthesis.

Malonic Acid, NaOAc

AcOH, Ac₂O
110 °C, 2 h
49 % (2 steps)

This step is from the synthesis of Strychnine by Joan Bosch. Show me the full synthesis.

Malonic Acid, NaOAc

AcOH, Ac₂O
110 °C, 2 h
49 % (2 steps)

This step is from the synthesis of Strychnine by Tohru Fukuyama. Show me the full synthesis.

Malonic Acid, NaOAc

AcOH, Ac₂O
110 °C, 2 h
42 % (4 steps)

This step is from the synthesis of Strychnine by Masakatsu Shibasaki. Show me the full synthesis.

Malonic Acid, NaOAc

AcOH, Ac₂O
110 °C, 2 h
42 % (2 steps)

This step is from the synthesis of Strychnine by Martin E. Kuehne. Show me the full synthesis.

Malonic Acid, NaOAc

AcOH, Ac₂O
110 °C
65 %

This step is from the synthesis of Strychnine by David W. C. MacMillan. Show me the full synthesis.

Malonic Acid, NaOAc

AcOH, Ac₂O
120 °C, 2 h
69 %

This step is from the synthesis of Hirsutene by Michel Franck-Neumann. Show me the full synthesis.

HCl

THF, H₂O
40 °C, 24 h
84 % (2 steps)

This step is from the synthesis of Corannulene by Jay S. Siegel. Show me the full synthesis.

KOH

MeOH
RT, 30 min
85 %